Multiple two-way SSL client Profiles - possible?

Ditto. You can switch the SSL profile based on the SNI in the Client Hello message...but the client cert comes to the server (BIG-IP) a few messages later and after a profile has been selected (after the Server Hello message and algorithm decision, Server Cert message, etc.). By the time you get to Client Cert it's too late to switch.

Is there a specific reason you need/want to do this, other than just keeping the CA bundles lite?