Load Balancing with limited Source IP

I am assuming you are not using source IP based persistence as the default or fallback persistence profile.

For persistence cookie insert, F5 inserts the cookie that provides information on the pool and member. Just the cookie insert persistence profile along with oneconnect persistence profile will provide the required persistence for CDN environment. I would recommend trying this out again as this is the simplest implementation that you would need. Flush any cache on the CDN side and then re-try this implementation.

If you are concerned about uneven load balancing, you can try to utilize /32 netmask in the oneconnect profile. There will be some uneven load balancing with oneconnect as described in K10430.