Load Balancing between On-Prem server and Azure Cloud server

MattAlex1 The reason I would not recommend you load balancing directly over the internet is because not you have introduced a new possible attack vector between your load balancer and the destination over the internet. If you had a VPN between the F5 environment and the Azure environment then you know both networks are trusted so for the most part you don't have to worry about someone between you and Azure spoofing the connection. I would like to note that AubreyKingF5 does bring up a great option that will remove the F5 from the Azure side of the connections allowing for DNS load balancing and then LTM load balancing on the site that has it when the DNS request lands on that side. You will remove a bit of load balancing capability because instead of say you have a pool of 3 PVWA and 3 PSM which would include the 3rd as the Azure side you now have 2 PVWA and 2 PSM with the GSLB setup with one of those hosts actually having 2 hosts behind it. This is a simple option that would work well and can most likely be tuned to add more weight to the DNS response for the LTM to help balance the connections evenly.