Is it possible to have BIG IP APM portal access to check computer membership

There's a couple of options for this try to get NTLM set up (there are couple of links on devcentral to do this). By doing this it will allow you to see if the user that's hitting F5 APM is on a domain join machine because it will be sending an NTLM token on behalf of the user. The other option is inspecting the IP of the incoming request (this is limited through especially if you allow other devices on the network). Install machine certificates (a lot of work with this one).

I was looking for the same thing but nothing panned out for me.