Irule for restricting access

Hello, you should be able to do this either with iRule or with LTM policy. 
F5 recommends using options available in standard configurations / GUI / traffic profiles over iRule syntax where possible, as they typically perform faster. 

In your case however using data group lists might be easier to mantain. One IP type data group to list restricted networks, and one string type data group to list restricted URI's. 

if { class match [HTTP::path] ends_with restricted_uri_class && class match [IP::client_Addr] equals restricted_ip_class } { reject }