iRule for non http services

Yes, I am 100% sure traffic is hitting the VIP. I saw it in sys connection tcp dump as well. Below is the scenario. 

There is an app on user desktop which is using content C:\Program Files (x86)\Proficy\Proficy WebSpace Client\Client\Proficy.exe -h VIP -f 0 -a  URI2" to access the application on LB. 

As there are three different pool serving different service, I didn`t call any of the pool in VIP resources instead I am applying iRule while when I remove the iRule and call a dedicated pool under VIP resource, that perticular application start working. 

Hope, it gives you more clarity about the requirement and troublwhooting I have done till now. 

Thanks,