iRule for non http services

Hello Paulius zamroni777 thanks for the response. Regarding http profile, I have already applied it. One thing I would like to tell you that this application is not being access via web browser, it is being accessed via a desktop application so not sure if that would be considered http traffic or not. 
I will try iRule shared by Paulius as well to check if this resolve the issue. 

I checked sys connection as well and it is showing any6.any any6.any after traffic hitting the VIP but no traffic showing on iRule.