IPSec on F5-Cisco

I don't recommend using a wildcard virtual server to handle IPsec traffic because of the security implications.

It's better to create a Virtual Server that handles the specific private subnets. You might have to create a Virtual Server for each direction, otherwise traffic cannot be established in both directions unless your local and remote private networks were both in 10.0.0.0/8 for example, then in that case one VS can cover traffic being established in both directions.

In the two Virtual Server scenario, one needs to listen on the internal side VLAN and the other needs to listen on the public side VLAN. In the one Virtual Server scenario, for bi-directional connection establishment, it needs to listen on both the internal and external side VLANs.

Remember that the Virtual Server does not actually handle the IPsec (ISAKMP and ESP) it handles the private network traffic.