How to prevent HTTP response splitting

I have a URL which is working fine when access it with its domain name but cannot access with its IP address.

There is no issue with server.

when I append some strings to that URL like for example

URL_domain_name.com/main%0d%0ahttp://www.example.com , it is showing some error messages which means HTTP header injection is prevented.

But when using same URL with its IP address like below

URL_IPaddress/main%0d%0ahttp://www.example.com , it is redirecting to www.example.com which causes HTTP header injection that should be prevented.

Does any one knows how to prevent this

HTTP response splitting::Header injection possible

Thanks

swapna