find cause for the issue : 01150306:3: Error connecting to named socket 'Connection refused'.

There are no qkview logs which can tell what went wrong with the bind.

The possible issue seems with the named service

Debug log for zrd and bind needs to be captured if the event occurs frequently to identify the possible reason behind this error.

Below article for capturing zrd and bind logs:

https://support.f5.com/csp/article/K14680

The workaround will be to restart the 'named' and 'zrd'.