F5 route domain configuration

I believe this is what you're looking for. Typically you don't separate route domains by external and internal, usually route domains are split by different segments such as DMZ, INSIDE, and so on. So if the F5 is in path for each domain then you would have a client and server facing interface paired together in each route domain and then make sure you have strict isolation enabled, this is the default behavior but it's always good to verify.

https://techdocs.f5.com/kb/en-us/products/big-ip_ltm/manuals/product/tmos-routing-administration-11-6-0/8.html

Hi Please be aware that if you are thinking of creating a VS with route domain 20 and the nodes with RD 30 it may not work you must check this KB : 

https://my.f5.com/manage/s/article/K84417414

Amr_Ali

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Thanks.