F5 and Anonymous Public facing SharePoint sites

Did you saw this irule? https://devcentral.f5.com/wiki/iRules.ACCESS__disable.ashx

If you have sharepoint sites running on the same hosts but they have different paths:

Such as: sharepoint.example.com/anonymous1; sharepoint.example.com/anonymous2; sharepoint.example.com/anonymous3

when HTTP_REQUEST {

    Check the requested HTTP path
   switch -glob [string tolower [HTTP::path]] {
          "/anonymous1*" -
          "/anonymous2*" -
          "/anonymous3*" {
                  Disable APM for these paths
                 ACCESS::disable
          }
          default {
                  Enable APM for all other paths
                 ACCESS::enable
          }
   }

}