Exchange 2010 load balanced via BIG-IP

Hi Domel-

There's no problem locating the CAS servers on the same subnet/VLAN (often called a "one-armed" topology). If you use the iApp to do your configuration, it will automatically create a "SNAT" to enable return traffic to get back to the BIG-IP without requiring routing changes on the CAS servers.

Where did you hear the information about Autodiscover? It's incorrect. And DAGs don't use Autodiscover. In fact, I believe recommended configuration from Microsoft is to have a dedicated network for DAG replication, and that wouldn;t be a network to which client traffic would ever have access.