Encrypting HTTP traffic to SSL on LTM

OK, so even if the servers are not responding to the partner's packets, and the packets aren't returning through an existing connection in BIG-IP, we still use a server ssl profile and it will automatically encrypt traffic that the LTM is seeing for the first time? I just want to make sure I'm understanding this correctly, because the LTM essentials course was stating that server ssl profiles were for "return" traffic - it didn't say anything about fresh traffic that's being initiated internally.