Does F5 load balancer intelligent in case of ports are down

It depends on where you've added your health monitor and how you've configured it

Typical scenario: you want the other ports to remain active after a single port has stopped responding

You need to have configured several pools, each with their own port, eg

PoolA:

name: http_pool

members: 10.10.10.10:80, 10.10.10.12:80

monitor: tcp_half_open (no port denfined in the monitor settings)

PoolB

name: https_pool

members: 10.10.10.10:443, 10.10.10.12:443

monitor: tcp_half_open (no port denfined in the monitor settings)

If 443 stops responding 80 will still work. Same if it is the other way around.

The monitor can be configured in the GUI

Selecting a monitor: Local Traffic > Pool > Select your pool > find the monitor in the right window and move it to the left

Creating a custom monitor: Local Traffic > Monitor > Create