Does ASM offers an iControl API to enable or disable an individual attack signature ?

Hello Alok,

Yes, you can send RESTAPI PATCH request to /mgmt/tm/asm/policies/policy_id/signatures/signature_id and set "enabled" to true or false.

Thanks, Ivan

This link may be helpful: https://clouddocs.f5.com/products/big-iq/mgmt-api/v6.1.0/HowToSamples/bigiq_public_api_wf/asm/t_update_policy_signatures.html