BigIQ 5.3 clustering between datacenters

Trying to figure out if a BigIQ 5.3 cluster can be created when the BigIQ devices are in entirely different locations and in different subnets. The guides I have seen so far just reference going through the steps of adding the second device as a peer to the first device and whatnot, but don't saying anything if there is or is not a requirement for them to have a common network between them.

Thanks in advance!