Append https URL with 8443 port

It seems to me that all you need is to have the pool members on port 8443 (or 4443 as in the diagram?). There is no reason why this would not work. Changing the host header to include :8443 would actually break the connection, since the browser does no consider the port part of the HOST.

Hi TSP, It could be ssl communication issue between LTM and pool members. Are you able to access your application directly bypassing LB ? does 3-way handshake and certificate exchange completed successfully on server side ? openssl & ssldump will be really helpful in this situation to clear out ssl communication issue.

Yes seems to be a SSL issue we have taken a tcpdump & ssldump for same & TAC is analyzing it for us will update with results