Anti-Spam behind F5 LTm

Thanks Kolom

However I need to allow the Anti-Spam node to initiate a connection to the internet on port 3888 is that option applicable ?

what I understood from this link that forwarding Virtual server is based on the destination port on the internal node while what I am asking for is how can I allow connection from internal node to internet on destination ports like 3888, 9993 ect., ?

Did you get my point

Thanks