Simplifying and Securing Network Segmentation with F5 Distributed Cloud and Nutanix Flow
Introduction Enterprises often separate environments—such as development and production—to improve efficiency, reduce risk, and maintain compliance. A critical enabler of this separation is network segmentation, which isolates networks into smaller, secured segments—strengthening security, optimizing performance, and supporting regulatory standards. In this article, we explore the integration between Nutanix Flow and F5 Distributed Cloud, showcasing how F5 and Nutanix collaborate to simplify and secure network segmentation across diverse environments—on-premises, remote, and hybrid multicloud. Integration Overview At the heart of this integration is the capability to deploy a F5 Distributed Cloud Customer Edge (CE) inside a Nutanix Flow VPC, establish BGP peering with the Nutanix Flow BGP Gateway, and inject CE-advertised BGP routes into the VPC routing table. This architecture provides full control over application delivery and security within the VPC. It enables selective advertisement of HTTP load balancers (LBs) or VIPs to designated VPCs, ensuring secure and efficient connectivity. By leveraging F5 Distributed Cloud to segment and extend networks to remote location—whether on-premises or in the public cloud—combined with Nutanix Flow for microsegmentation within VPCs, enterprises achieve comprehensive end-to-end security. This approach enforces a consistent security posture while reducing complexity across diverse infrastructures. In our previous article (click here) , we explored application delivery and security. Here, we focus on network segmentation and how this integration simplifies connectivity across environments. Demo Walkthrough The demo consists of two parts: Extending a local network segment from a Nutanix Flow VPC to a remote site using F5 Distributed Cloud. Applying microsegmentation within the network segment using Nutanix Flow Security Next-Gen. San Jose (SJ) serves as our local site, and the demo environment dev3 is a Nutanix Flow VPC with an F5 Distributed Cloud Customer Edge (CE) deployed inside: *Note: The SJ CE is named jy-nutanix-overlay-dev3 in the F5 Distributed Cloud Console and xc-ce-dev3 in the Nutanix Prism Central. On the F5 Distributed Cloud Console, we created a network segment named jy-nutanix-sjc-nyc-segment and we assigned it specifically to the subnet 192.170.84.0/24: eBGP peering is ESTABLISHED between the CE and the Nutanix Flow BGP Gateway in this segment: At the remote site in NYC, a CE named jy-nutanix-nyc is deployed with a local subnet of 192.168.60.0/24: To extend jy-nutanix-sjc-nyc-segment from SJ to NYC, simply assign the segment jy-nutanix-sjc-nyc-segment to the NYC CE local subnet 192.168.60.0/24 in the F5 Distributed Cloud Console: Effortlessly and in no time, the segment jy-nutanix-sjc-nyc-segment is now extended across environments from SJ to NYC: Checking the CE routing table, we can see that the local routes originated from the CEs are being exchanged among them: At the local site SJ, the SJ CE jy-nutanix-overlay-dev3 advertises the remote route originating from the NYC CE jy-nutanix-nyc to the Nutanix Flow BGP Gateway via BGP, and installs the route in the dev3 routing table: SJ VMs can now reach NYC VMs and vice versa, while continuing to use their Nutanix Flow VPC logical router as the default gateway: To enforce granular security within the segment, Nutanix Flow Security Next-Gen provides microsegmentation. Together, F5 Distributed Cloud and Nutanix Flow Security Next-Gen deliver a cohesive solution: F5 Distributed cloud seamlessly extends network segments across environments, while Nutanix Flow Security Next-Gen ensures fine-grained security controls within those segments: Our demo extends a network segment between two data centers, but the same approach can also be applied between on-premises and public cloud environments—delivering flexibility across hybrid multicloud environments. Conclusion F5 Distributed Cloud simplifies network segmentation across hybrid and multi-cloud environments, making it both secure and effortless. By seamlessly extending network segments across any environment, F5 removes the complexity traditionally associated with connecting diverse infrastructures. Combined with Nutanix Flow Security Next-Gen for microsegmentation within each segment, this integration delivers end-to-end protection and consistent policy enforcement. Together, F5 and Nutanix help enterprises reduce operational overhead, maintain compliance, and strengthen security—while enabling agility and scalability across all environments. This integration is coming soon in CY2026. If you’re interested in early access, please contact your F5 representative. Related URLs Delivering Secure Application Services Anywhere with Nutanix Flow and F5 Distributed Cloud | DevCentral F5 Distributed Cloud - https://www.f5.com/products/distributed-cloud-services Nutanix Flow Network Security - https://www.nutanix.com/products/flow
