BIG-IP vWire Configuration

As a fast note after checking some stuff I saw that in 15.1.x vWire does not support self-ip or ARP/Proxy ARP so NAT seems not an option but in 16.1.3.2 ARP and SELF-IP for vWires are supported so NAT probably can work there (have not tested NAT on 16.1.3 to 100% confirm this) but for NAT or IPS/port misuse  as I see it Layer 3 AFM/LTM deployments are better.